Uses - Silica Gel
The excipients' reactions to various factors, such as heat, moisture, temperature, and oxygen, determine the stability of drugs. Drug instability can be caused by these factors, chemically, biologically or physically. Shelf-life is another term for stability. Shelf-life is the time that the drug must remain potent and be safe for consumption. Drug instability can cause loss of active drug, bioavailability decrease, and the creation of toxic substances. Instability can be caused by moisture. Protecting the drug against moisture is crucial with silica gel sachets. These sachets trap moisture in the packaging and prevent moisture entering the container. This increases shelf life. Moisture can cause hydrolysis of drugs. Drug degradation is often caused by hydrolysis. Water is the solvent in most pharmaceutical formulations. Many esters and amide drugs can be hydrolyzed in water. Water can also be used as a catalyst for microbial growth and as a vehicle. To stop drug hydrolysis, silic...
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